| 何娟娟,刘立新.长链非编码RNA与心肌凋亡[J].济宁医学院学报,2022,45(1):54-58 |
| 长链非编码RNA与心肌凋亡 |
| Long non-coding RNA and myocardial apoptosis |
| 投稿时间：2021-03-19 |
| DOI：10.3969/j.issn.1000-9760.2022.01.012 |
| 中文关键词: 长链非编码RNA 心肌凋亡 心血管疾病 |
| 英文关键词: Long Non-Coding RNA Myocardial apoptosis Cardiovascular disease |
| 基金项目:山东省医药卫生科技发展计划项目基金（2019WSB34001） |
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| 中文摘要: |
| 长链非编码RNA（long non-coding RNA，lncRNA）是转录本长度超过200个核苷酸且不具有功能性蛋白质编码能力的RNA转录物，其在心血管疾病中的表达存在差异。心肌凋亡是导致多种心血管疾病的重要病理过程，lncRNA可通过多种途径影响心肌凋亡。本文就lncRNA与心肌凋亡关系的研究进展做一综述，总结lncRNA通过调节心肌细胞凋亡影响心血管疾病的机制。 |
| 英文摘要: |
| Long non-coding RNA(LncRNA)is a kind of RNA transcript with a length of more than 200 nucleotides and no functional protein coding ability.There are differences in the expression of LncRNA in cardiovascular diseases.Myocardial apoptosis is an important pathological process leading to a variety of cardiovascular diseases.LncRNA can affect myocardial apoptosis in a variety of ways.This paper reviewed the research progress of the relationship between LncRNA and myocardial apoptosis, and summarized the mechanism of LncRNA affecting cardiovascular disease by regulating cardiomyocyte apoptosis. |
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