| 刘利娟,李傲.SphK1/S1P信号通路在肺纤维化发生中的作用[J].济宁医学院学报,2019,42(6):424-427 |
| SphK1/S1P信号通路在肺纤维化发生中的作用 |
| The role of SphK1/S1P signaling pathway in pulmonary fibrosis |
| 投稿时间：2019-06-10 |
| DOI：10.3969/j.issn.1000-9760.2019.06.011 |
| 中文关键词: 1-磷酸鞘氨醇 1-磷酸鞘氨醇受体 鞘氨醇激酶 肺纤维化 |
| 英文关键词: Sphingosine 1-phosphate Sphingosine 1-phosphate receptors Sphingosine kinases Pulmonary fibrosis |
| 基金项目:国家自然科学基金（81703687）；重庆市卫生和计划生育委员会中医药科技项目（ZY201702122）；重庆理工大学研究生创新项目（ycx2018250） |
|
| 摘要点击次数: 4629 |
| 全文下载次数: 6628 |
| 中文摘要: |
| 纤维化是一种病理过程，其以细胞外基质（extracellular matrix，ECM）的大量沉积为主要特征。纤维化发生在包括肺、肝脏、心脏和肾脏在内的各种器官中，最终导致器官结构扭曲和严重功能障碍。1-磷酸鞘氨醇（sphingosine-1-phosphate，S1P）是一种具有生物活性的溶血磷脂，发挥多种活性，包括细胞增殖、存活、分化、迁移、炎症、血管生成和内皮屏障完整性等过程。越来越多的证据表明，SphK1/S1P信号通路在肺纤维化疾病的发生发展中起着重要作用，研究其相关作用与功能，可为治疗难治性纤维化性疾病提供新的思路和药物治疗靶点。 |
| 英文摘要: |
| Fibrosis is a pathological process characterized by massive deposition of extracellular matrix (ECM).Fibrosis occurs in various organs including the lung,liver,heart,and kidney,eventually leading to structural distortion and severe dysfunction.Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid that exerts a variety of activities including cell proliferation,survival,differentiation,migration,inflammation,angiogenesis,and endothelial barrier integrity.Many studies suggests that SphK1/S1P signaling pathway plays an important role in the occurrence and development of pulmonary fibrosis.The functional mechanisms of S1P would provide potential therapeutic strategies and targets for refractory fibrotic diseases. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
