| 孙炜炜,邵泽伟.DNA甲基化异常与白血病微小残留病[J].济宁医学院学报,2017,40(4):301-304 |
| DNA甲基化异常与白血病微小残留病 |
| Abnormal DNA methylation and minimal residual disease in leukemia |
| 投稿时间：2017-04-13 |
| DOI：10.3969/j.issn.1000-9760.2017.04.016 |
| 中文关键词: DNA甲基化 白血病 微小残留病 |
| 英文关键词: DNA methylation Leukemia Minimal residual disease |
| 基金项目:济宁医学院青年教师科研扶持基金（JY2016 KJ022Y）；济宁市科技发展计划项目（2016-56-82）；济宁医学院大学生创新训练计划项目（cx2016007） |
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| 中文摘要: |
| 微小残留病（minimal residual disease，MRD）是白血病患者复发的主要根源，严重影响患者的生存质量。DNA甲基化是一种重要的表观遗传学调控机制，与白血病的发生发展关系密切。肿瘤相关基因DNA甲基化的异常改变可作为一种分子标志物用于监测白血病MRD，预测疾病复发、指导临床治疗和判断预后。本文就近年来相关基因DNA甲基化异常与白血病MRD之间的研究作一简要综述。 |
| 英文摘要: |
| Minimal residual disease (MRD) in leukemia is the main cause of recurrence,which seriously affects the patients' quality of life.DNA methylation is an important epigenetic regulation mechanism,which is closely related to the occurrence and development of leukemia.The abnormal DNA methylation changes of tumor related genes can be used as a molecular marker for monitoring MRD,which could predict disease recurrence,guide clinical treatment and judge prognosis.The research of abnormal DNA methylation of related genes and MRD in leukemia are summarized in this paper. |
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