| 冯新新,王克勤.抑郁症患者抗抑郁治疗无效后换药方法文献综述[J].济宁医学院学报,2017,40(3):209-213 |
| 抑郁症患者抗抑郁治疗无效后换药方法文献综述 |
| Literature review of the switch antidepressants when antidepressant treatment is ineffective |
| 投稿时间：2017-03-03 |
| DOI：10.3969/j.issn.1000-9760.2017.03.014 |
| 中文关键词: 抗抑郁药 换药策略 戒断反应 5-HT综合征 药物清洗 |
| 英文关键词: Antidepressants Switching strategy Withdrawal reaction 5-HT syndrome Drug washout |
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| 中文摘要: |
| 初次抗抑郁药治疗后，约2/3抑郁患者症状未能得到有效缓解。另外，还有部分患者因无法耐受的副反应、经济状况以及个人偏好等因素无法继续原药治疗。因此，换用抗抑郁药是临床上非常普遍的现象。本文参考了大量国内外相关文献资料，对初次抗抑郁药治疗失败后换药的有效性、换药时机、更换药物选择、换药策略、换药风险等问题进行综述，以供临床医师参考。 |
| 英文摘要: |
| About two-thirds of patients with major depressive disorder do not relieve effectively after the initial antidepressant monotherapy treatment.Additionally,some patients can not continue the original treatment due to the intolerable side-effects,financial problems,personal preferences and other factors.Therefore,switching antidepressants is very common in actual clinical practice.At present,according to a great number of foreign relevant literatures,the major problems of switching antidepressants are summarized,including the efficacy,the appropriate timing and antidepressant,the switching strategies,the risks and so on,which provide the references for psychiatrists. |
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