| 刘婷婷,于世鹏.Sirtuin2对糖脂代谢调节作用的研究进展[J].济宁医学院学报,2017,40(1):59-62 |
| Sirtuin2对糖脂代谢调节作用的研究进展 |
| Research progress in the regulation of glucose and lipid metabolism by sirtuin2 |
| 投稿时间：2016-10-17 |
| DOI：10.3969/j.issn.1000-9760.2017.01.015 |
| 中文关键词: SIRT2 糖代谢 脂质代谢 |
| 英文关键词: SIRT2 Lipid metabolism Glucose metabolism |
| 基金项目: |
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| 摘要点击次数: 6855 |
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| 中文摘要: |
| 目的 沉默信息调节因子（silent information regulator 2，SIRT2）也称sirtuin2属于依赖烟酰胺腺嘌呤（NAD+）去乙酰化酶家族，以组蛋白及非组蛋白为靶点。据报道，SIRT2参与调节脂类代谢、糖代谢、氧化应激、炎症反应等病理生理过程。本文将对SIRT2参与糖脂代谢作用的研究新进展作一综述。 |
| 英文摘要: |
| Sirtuin2 (SIRT2,silent information regulator 2) is an NAD+-dependent deacetylase,which targets both histone and non-histone proteins for deacetylation.It has been reported that SIRT2 participates in many pathophysiologic processes,such as lipid metabolism,glucose metabolism,inflammatory and oxidative stress.The purpose of this review is to summarize the most recent findings about SIRT2 in glucose and lipid metabolism. |
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