| 韩艳艳,于世鹏.SIRT7研究进展[J].济宁医学院学报,2016,39(5):353-356,361 |
| SIRT7研究进展 |
| The recent advance in SIRT7 |
| 投稿时间：2015-10-03 |
| DOI：10.3969/j.issn.1000-9760.2016.05.014 |
| 中文关键词: SIRT7;催化活性;细胞应激;疾病;衰老 |
| 英文关键词: SIRT7;Catalytic activity;Cell stress;Disease;Aging |
| 基金项目: |
| 作者 | 单位 | | 韩艳艳 | 济宁医学院附属医院兖州院区, 济宁 272029 | | 于世鹏 | 济宁医学院附属医院兖州院区, 济宁 272029 |
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| 中文摘要: |
| SIRT7是Sirtuins蛋白家族（组蛋白去乙酰化酶类）成员之一，位于17号亚染色体（17q25.3）的单拷贝基因。以往研究多集中在SIRT1~SIRT6，近年来，随着对SIRT7研究的不断深入，发现其对特定底物具有脱乙酰化物酶的活性，可通过多种途径参与基因转录、蛋白质合成、染色体重构及细胞应激等过程的调节。此外，SIRT7还参与相关疾病及衰老的发生发展过程。本文就近年来SIRT7研究进展作一综述。 |
| 英文摘要: |
| Objective SIRT7 is one member of sirtuins protein family (histone deacetylase complex enzymes),which is a single copy gene located on chromosome 17 (17q25.3).Previous studies mostly focused on SIRT1~SIRT6.In recent years,SIRT7 showed acetylate enzyme activity in some studies.And SIRT7 could regulate gene transcription,protein synthesis,chromosome remodeling and cell stress and other processes of regulation through a variety of ways.In addition,it is involved in the regulation of related diseases and the occurrence and development of aging.The present work makes a brief review of the mechanism of SIRT7 involved in the process. |
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