| 陈祥娥.肝素原应用研究进展[J].济宁医学院学报,2015,(3):153-155,158 |
| 肝素原应用研究进展 |
| Progress on the application of heparosan |
| 投稿时间：2015-05-26 |
| DOI：10.3969/j.issn.1000-9760.2015.03.001 |
| 中文关键词: 肝素前体;肝素;药物载体;肠道菌群 |
| 英文关键词: Heparosan;Heparin;Drug carrier;Intestinal flora |
| 基金项目: |
| 作者 | 单位 | | 陈祥娥 | 济宁医学院生物科学学院, 山东日照 276826 |
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| 中文摘要: |
| 肝素原(heparosan)是某些细菌荚膜中多糖骨架的二糖重复单位,同时也是肝素和硫酸乙酰肝素的生物合成前体。以发酵获得的肝素原为前体骨架多糖,采用化学或生物修饰生产肝素及其类似物是目前非动物来源肝素生产的研究热点。近来发现,肝素原还可作为良好的药物载体,具有调节肠道菌群等作用。本文对其应用研究作一综述。 |
| 英文摘要: |
| Heparosan is a polysaccharide found in the capsule of certain bacteria,as well as the biosynthesis precursor of heparin and heparan sulfate of animals.Now researches mainly focus on the non-animal origin production of heparin which employs chemical or biological modifications and takes the heparosan from fermentation as precursor.It has been recently found that heparosan can serve as a good drug carrier and regulate the intestinal flora and so on.This article reviews the latest progress of its application. |
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