| 4—硒硫酸酯多糖对人肝癌细胞Bel／7402DNA RNA及蛋白质合成的影响 |
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| 引用本文： | 戴伟娟,仲伟法,索金良,林志彬.4—硒硫酸酯多糖对人肝癌细胞Bel／7402DNA RNA及蛋白质合成的影响[J].济宁医学院学报,2001,24(1):18-19. |
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| 作者姓名： | 戴伟娟 仲伟法 索金良 林志彬 |
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| 作者单位： | 1. 济宁医学院药理学教研室
2. 北京医科大学 |
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| 摘 要： | 目的 研究4－硒硫酸酯多糖体外给药对人肝癌细胞Bel/7402DNA.RNA及蛋白质的抑制作用。方法 肿瘤细胞与不同浓度的药物培养24h后，用同位素掺入实验，观察药物对肿瘤细胞DNA、RNA及蛋白质合成的影响。结果 4－硒硫酸酯多糖可抑制肿瘤细胞DNA、RNA及蛋白质合成。结论 4－硒硫酸酯多糖对瘤细胞生长的抑制作用，可能与抑制瘤细胞DNA、RNA及蛋白质合成有关。
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| 关 键 词： | 4－硒硫酸酯多糖 肿瘤细胞 DNA RNA 蛋白质 肝癌 |
INHIBITORY EFFECTS OF SE- CARRA ON DNA,RNA AND PROTEIN SYNTHESIS OF HUMAN
HEPATOCARCINOMA CELLS BEL/7402 IN VITRO |
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| Dai Weijuan,Zhong Weifa,Suo Jinliang,et al.INHIBITORY EFFECTS OF SE- CARRA ON DNA,RNA AND PROTEIN SYNTHESIS OF HUMAN
HEPATOCARCINOMA CELLS BEL/7402 IN VITRO[J].Jounal of Jinning Medical College,2001,24(1):18-19. |
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| Authors: | Dai Weijuan Zhong Weifa Suo Jinliang |
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| Abstract: | Objective To study inhibitory effects of Se-carra on DNA,RNA and protein synthesis of human hepatocarcinoma cells Bel/7402 in vitro Methods tumor cells were cultured for 24h with different drug densities Inhibitory effects of Se-carra on DNA,RNA and protein synthesis of tumor cells were observed by isotope incorporation experiment Results the results showed that Se-carra could inhibit the DNA,RNA and protein synthesis of the human hepatic carcinoma cell Lines Bel/7402,and its action of interfereing with DNA synthesis was the best Conclusion the results indicated that Se-carra has obviously depressing effects on DNA synthesis of liver cancer cells in vitro It is probable that these effects are related to antineoplastic activity |
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| Keywords: | Se-carra Tumor cells DNA RNA Protein |
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