| Objective To explore the effects of hyperbaric oxygen (HBO) on cerebral atherosclerotic inflammation and oxidative stress in rats. Methods SD rats were randomly divided into control group, model group and HBO group. The model was constructed using a high-fat diet combined with L-NAME feeding. Hyperbaric oxygen chamber was adopted to implement HBO treatment. Serum was collected from the rats at the end of the treatment to detect the levels of blood lipid, inflammation and oxidative stress. Results Serum levels of TG, TC, TNF-α, IL-1β, IL-6 and MDA in the HBO group were (1.14±0.5) mmol/L,(3.95±1.1) mmol/L,(1.87±0.6) μg/L, (206.73±30.6) pg/mL, (104.51±12.2) pg/mL and (25.75±6.2) mmol/L, respectively, which were lower than those in the model group. The contents of HDL-C, IL-10, SOD and GSH-Px were (0.65±0.2)mmol/L, (47.98±14.9)pg/mL, (379.50±82.5)U/mL and (790.69±93.0)U/mL, respectively, which were higher than those in the model group. There were statistical differences between the groups (P<0.05). Conclusion HBO can reduce blood lipid levels in rats with cerebral atherosclerosis, improve the ability to resist oxidative stress, thereby reducing the inflammatory response. |
