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| Syndecans在人结直肠癌发生发展中的作用 |
| The role of Syndecans in the development of human colorectal cancer |
| 投稿时间：2019-01-31 修订日期：2019-04-09 |
| DOI： |
| 中文关键词: 结直肠癌;Syndecans;治疗;预后 |
| 英文关键词: Colorectal cancer; Syndecans;Treatment; Prognosis |
| 基金项目:国家自然科学基金(81802945) |
| 作者 | 单位 | 邮编 | | 吴晓晓 | 济宁医学院临床医学院 | 272067 | | 王卫 | 济宁医学院附属医院病理科 | | | 崔文* | 济宁医学院临床医学院 | 272067 |
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| 中文摘要: |
| 结直肠癌（Colorectal cancer，CRC）是全球第三大常见癌症，常在疾病晚期被明确诊断，预后较差。因此，了解结直肠癌的病程进展和预后分子标志物，对于确定治疗方案和改善生存率至关重要。Syndecans是一种硫酸乙酰肝素蛋白多糖，具有重要的生理病理作用，如参与肿瘤粘附、侵袭和转移等，是开发新的诊断方法和治疗药物的潜在分子靶向标志物。Syndecans的表达或缺失与结直肠癌的预后相关，本文综述了Syndecans与结直肠癌肿瘤发生发展的关系，以此期望为诊断和治疗结直肠癌提供新的靶点。 |
| 英文摘要: |
| Colorectal cancer (CRC) is the third most common cancer in the world, and is often diagnosed in the late stage of the disease with a poor prognosis. Therefore, understanding the progression of the colorectal cancer and the molecular markers of prognosis are critical to determining treatment options and improving survival. Syndecans is a heparan sulfate proteoglycan that has important physiological and pathological effects, such as involvement in tumor adhesion, invasion and metastasis, and is a potential molecular targeting marker for the development of new diagnostic methods and therapeutic drugs. The expression or deletion of Syndecans is associated with the prognosis of colorectal cancer. This article reviews the relationship between Syndecans and the development of colorectal cancer, which is expected to provide a new target for the diagnosis and treatment of colorectal cancer. |
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