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| Sirtuins与冠心病? |
| Sirtuins and coronary heart disease |
| 投稿时间：2018-06-07 修订日期：2018-11-08 |
| DOI： |
| 中文关键词: Sirtuins家族；冠心病；应激；代谢 |
| 英文关键词: Sirtuins family; Coronary heart disease; Stress; Metabolism |
| 基金项目:心脏特异性转录因子基因调控区域与先天性心脏病的分子遗传学研究,国家自然科学基金项目（面上项目，重点项目，重大项目） |
| 作者 | 单位 | 邮编 | | 程纷纷 | 济宁医学院 | 272067 | | 闫波* | 济宁医学院附属医院 | 272029 |
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| 中文摘要: |
| 沉默信息调节因子（Sirtuins）家族是一类高度保守的第III类去乙酰化酶，主要依赖烟酰胺腺嘌呤（NAD+）作为辅酶发挥其生物学功能。Sirtuins调控多种细胞过程，如基因转录、炎症反应、代谢、细胞应激等，并参与癌症、糖尿病、心血管疾病及神经性疾病等多种疾病的发生和发展。已有研究发现，Sirtuins可通过抗氧化、抗凋亡及抗炎等功能延缓冠心病的发生发展，在冠心病的发病中发挥重要作用。本文总结了近年来Sirtuins家族的研究进展，就其生物学功能和冠心病的相关性作一综述。 |
| 英文摘要: |
| Sirtuins family is a highly conserved class III deacetylase, which mainly relies on nicotinamide adenine (NAD+) as a coenzyme. Sirtuins regulate a variety of cellular processes, such as gene transcription, inflammation, metabolism, and cellular stress, and has been implicated in human diseases including cancer, diabetes, cardiovascular diseases and neurological diseases. In recent years, it has been reported that the Sirtuins family can delay the progression of coronary heart disease through anti-oxidation, anti-apoptosis and anti-inflammatory functions. In this review, we summarize the recent progress on Sirtuins family, focusing on the relationship between its biological functions and coronary heart disease. |
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