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| 矮小症儿童IGF-1水平与心外膜脂肪组织厚度的相关性研究 |
| Association between IGF-1 level and epicardial adipose tissue thickness in children with growth hormone deficiency |
| 投稿时间：2018-03-15 修订日期：2018-03-29 |
| DOI： |
| 中文关键词: 生长激素缺乏；心外膜脂肪；胰岛素样生长因子-1 |
| 英文关键词: Growth hormone deficiency; Epicardial adipose tissue; Insulin-like growth factor-1 |
| 基金项目:济宁市科技局资助项目，项目编号：济科字[2015]57号-11 ；山东省人口和计划生育委员会项目，项目编号：2014年第32号 |
| 作者 | 单位 | 邮编 | | 李艳英 | 济宁医学院附属医院 | 272000 | | 张梅 | 济宁医学院附属医院 | | | 刘丹丹 | 济宁医学院附属医院 | | | 朱惠娟 | 北京协和医院 | | | 李萍 | 济宁医学院附属医院 | | | 孙海玲 | 济宁医学院附属医院 | | | 班博* | 济宁医学院附属医院 | 272000 |
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| 中文摘要: |
| 目的 观察矮小症儿童患者胰岛素样生长因子（insulin-like growth factor-1，IGF-1)水平与心外膜脂肪组织（epicardial adipose tissue，EAT）厚度相关性，探讨相关影响因素及作用机制。方法 应用巢式病例对照研究方法，收集2017年1月-2017年10月在济宁医学院附属医院内分泌二科住院的青春期前矮小症患者32例，按照生长激素（Growth hormone,GH）激发试验结果将患者分为三组：A组：生长激素完全缺乏组（GHmax＜5ng/ml）；B组：生长激素部分缺乏组（5 ng/ml≤GHmax＜10 ng/ml）； C组：生长激素正常组（GHmax＞10 ng/ml）。应用超声心动图测得每例患者EAT厚度，同时收集患者的一般资料及血脂、GH、IGF-1、骨龄（Bone age,BA）等指标。结果 A组EAT厚度较B组及C组增加（P＜0.05），而B组与C组比较无差异（P＞0.05）；进行单因素分析与平滑曲线拟合发现与IGF-1及IGF-1SDS与EAT厚度无明显相关，进行分层及多因素分析发现，在A组EAT厚度与IGF-1SDS呈负相关（β=-0.6，95%CI-0.8, -0.2，P=0.025），而在B组（β=0.2，95%CI-0.3, 0.6，P= 0.523）及C组（β=0.1，95%CI-0.6, 0.8，P=0.753）均无明显相关性。结论 完全生长激素缺乏症儿童IGF-1SDS水平与EAT厚度呈显著负相关。 |
| 英文摘要: |
| Objective To observe the change of epicardial adipose tissue (EAT) thickness in children with growth hormone deficiency, and to explore the effect of metabolism with them. Methods Use nested case-control study method, collected 32 prepuberty children diagnosed with short stature in Affiliated Hospital of Jining Medical College, from January 2017 to October. According to the growth hormone stimulation test results, all patients were divided into three groups, group A: growth hormone deficiency group (GHmax < 5ng/ml); group B: partial growth hormone deficiency group (5 ng/ml≤GHmax < 10 ng/ml); group C: normal growth hormone group (GHmax≥10 ng/ml). Test everyones EAT thickness by echocardiography, while collecting general information and related results, such as blood lipid, growth hormone, insulin-like growth factor-1 (IGF-1) and bone age etc. Results EAT thickness is thicker in group A compared with group B and group C (P < 0.05), and there is no difference between group B and group C (P > 0.05). Single factor analysis and Smooth curve fitting found that EAT thickness isn’t related to IGF-1 and IGF-1SDS, stratified and multi-factor analysis showed that in A group EAT thickness was negatively correlated with IGF-1SDS (β =0.6，95%CI-0.8, -0.2，P=0.025), while in group B (β=0.2，95%CI-0.3, 0.6，P= 0.523) and group C (β=0.1，95%CI-0.6, 0.8，P=0.753) hadn’t been found. Conclusion The epicardial thickness in children with growth hormone deficiency was higher than that in the control group, and was negatively correlated with IGF-1SDS. |
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