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| 基于基因组学的天然产物研究 |
| Study on the genomic-driven discovery of biological natural products |
| 投稿时间：2018-01-15 修订日期：2018-04-02 |
| DOI： |
| 中文关键词: 天然产物；新药发掘；基因组学；组合生物合成 |
| 英文关键词: natural product; drug discovery; genomics; combinatorial biosynthesis |
| 基金项目: |
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| 中文摘要: |
| 天然产物由于其结构及生物活性的多样性，一直是药物研发的一个重要来源。但是在过去的一段时间里，由于高通量筛选技术的制约，导致天然产物研究进展较为缓慢。近年来DNA测序技术的不断进步，从分子水平上对微生物次级代谢的研究，揭示了大自然在生产天然产物方面的非凡能力，这给新药研发提供了新的研究方向。基于基因组学的天然产物发现是一种理性的、高效的，建立在测序技术上的发掘新化合物的方法。而生物信息学和合成生物学技术的蓬勃发展则为天然产物的探索与结构改造提供了便利的技术手段。鉴于此，本论文将重点阐述基于基因组学的天然产物发现，包括其关键的步骤，相关的技术及涉及的成功应用。 |
| 英文摘要: |
| Natural products have been the main and rich source of components for novel drug discovery owning to the diverse structures and bioactivities. However, the technical barriers to screening natural products in high-throughput assays have made the natural product research slowdown in the past two decades. Recently, with the rapid development of DNA sequencing, research progresses on microbial metabolites have revealed the great potential of Nature to produce natural products, which throw new insights into novel drug development at the molecular level. Among them, genomic- driven drug discovery is an efficient and rational strategy to discover novel structures based on DNA sequencing. The thriving bioinformatics and synthetic biology will provide a fairly accessible way of exploring and modifying natural products. In this review, it is focused on the process of genomic-driven drug discovery, including the key steps and technical approaches. In addition, the successful examples are also highlighted. |
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