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| BRAFV600E和TERT启动子突变与甲状腺乳头状癌的相关性 |
| The correlation between BRAFV600E mutation and TERT promoter mutation with papillary thyroid carcinoma |
| 投稿时间：2017-06-12 修订日期：2018-05-04 |
| DOI： |
| 中文关键词: 甲状腺乳头状癌;BRAFV600E突变;TERT启动子突变 |
| 英文关键词: thyroid papillary carcinoma; BRAFV600Emutation; TERT promoter mutation |
| 基金项目:] 山东省教育厅山东省高等学校科技计划(J13LK14)△ [通讯作者] 崔文,E-mail:cuiwenmd@163.com |
| 作者 | 单位 | 邮编 | | 代丽丽 | 济南大学山东省医学科学院医学与生命科学学院 | 272067 | | 张国安 | 济宁医学院司法鉴定中心 | | | 崔文* | 济宁医学院法医学与医学检验学院 | 272067 |
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| 中文摘要: |
| 目的 甲状腺癌的发病率近年来呈快速上升的趋势,是内分泌系统最常见的恶性肿瘤,最常见的临床病理类型是甲状腺乳头状癌。在甲状腺乳头状癌的发生和发展中,有多种基因参与其中,近年研究发现TERT启动子突变和BRAFV600E基因突变在甲状腺乳头状癌的发生与发展中发挥着重要作用,可能与临床病理学特征和不良预后具有相关性。因此,正确全面了解TERT和BRAF基因在甲状腺乳头状癌中的突变特点以及相互作用有助于为甲状腺乳头状癌患者的预后判断和个体化诊治提供依据,从而为靶基因治疗奠定基础。 |
| 英文摘要: |
| Thyroid carcinoma is the most common malignant tumor of the endocrine system which rising rapidly in recent years. Papillary thyroid carcinoma is the commonest clinical pathological type. There are numbers of genes involved in the occurrence and development of thyroid papillary carcinoma. Recent years, some researchs found that the mutation of TERT promoter and BRAFV600E in thyroid papillary carcinoma plays an important role, which may be associated with clinical pathologic features and poor prognosis. Therefore, comprehensive understanding the mutation characteristics and interaction of TERT promoter and BRAFV600E gene in the thyroid papillary carcinoma helps to provides the basis for the judge prognosis and individualized treatment and lays the foundation for target gene therapy of papillary thyroid carcinoma . |
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