| 王东月,李运清.白色念珠菌菌丝的形成机制及防治[J].济宁医学院学报,2020,43(5):356-361 |
| 白色念珠菌菌丝的形成机制及防治 |
| The formation mechanism and prevention of candida albicans hyphae |
| 投稿时间：2020-06-29 |
| DOI：10.3969/j.issn.1000-9760.2020.05.012 |
| 中文关键词: 白色念珠菌;菌丝;毒力因子;分子调控 |
| 英文关键词: Candida albicans;Hyphae;Virulence factors;Molecule regulation |
| 基金项目:国家自然科学基金（31500056）；济宁医学院贺林院士新医学临床转化工作站科研基金（JYHL2019MS04） |
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| 摘要点击次数: 2008 |
| 全文下载次数: 3586 |
| 中文摘要: |
| 白色念珠菌是一种重要的条件致病性真菌，也是一种人体共生菌，可以在免疫缺陷或机体受损患者中引起活跃感染，导致念珠菌病的发生。近年来伴随着免疫缺陷患者不断增加，白色念珠菌引发的深部真菌感染越来越多，该病难以治愈且死亡率较高，念珠菌病的彻底治疗已成为临床上亟需解决的问题之一。而由于抗菌药物的滥用，白色念珠菌的耐药性不断增强，采用传统的治疗方法效果并不显著，因此对白色念珠菌的毒力因子（致病因素）进行研究以寻找新的治疗策略势在必行。白色念珠菌的菌丝是其重要的毒力因子，本文将从白色念珠菌菌丝的毒力作用、菌丝形成的分子调控机制、菌丝的免疫调节及抑制菌丝的小分子化合物等方面做一综述，为寻找和开发治疗药物和疫苗提供理论依据。 |
| 英文摘要: |
| Candida albicans is an important conditional pathogenic fungus.It is a human symbiotic bacterium.Patients with immune deficiency and body damage can be caused active infection by Candida albicans called candidiasis,which is an opportunistic infection disease.In recent years,with the increasing number of immunodeficiency patients,more and more deep fungal infections caused by Candida albicans have been found,and the disease,which is difficult to cure,can also cause a high mortality rate.The thorough treatment of candidiasis has become one of the problems that need to be solved clinically.However,due to the abuse of antibacterial drugs,the drug resistance of Candida albicans is increasing,and the traditional treatment methods have no significant effect.Therefore,it is imperative to further implement research on the virulence factor (pathogenic factor) of Candida albicans to find new therapeutic strategies.Hypha of Candida albicans is an important virulence factor,and in this paper the virulence of Candida albicans hyphae,molecular regulation mechanism of hyphae formation,immune regulation of hyphae and small molecular compounds that inhibit hyphae will be discussed to provide theoretical basis for the future search and development of therapeutic drugs and vaccines. |
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