| 张佳丰,于世鹏.他汀类药物抗甲状腺未分化癌作用机制研究进展[J].济宁医学院学报,2020,43(3):220-223 |
| 他汀类药物抗甲状腺未分化癌作用机制研究进展 |
| Research progress of mechanism of anaplastic thyroid cancer with statins |
| 投稿时间：2019-05-08 |
| DOI：10.3969/j.issn.1000-9760.2020.03.016 |
| 中文关键词: 甲状腺未分化癌;他汀;增殖;凋亡;再分化 |
| 英文关键词: Anaplastic thyroid cancer;Statins;Hyperplasia;Apoptosis;Redifferentiation |
| 基金项目: |
| 作者 | 单位 | E-mail | | 张佳丰 | 济宁医学院临床医学院, 济宁 272013
济宁医学院附属医院, 济宁 272029 | | | 于世鹏 | 济宁医学院临床医学院, 济宁 272013
济宁医学院附属医院, 济宁 272029 | yushipeng@vip-sina.com |
|
| 摘要点击次数: 1809 |
| 全文下载次数: 0 |
| 中文摘要: |
| 甲状腺癌是内分泌系统最常见的恶性肿瘤，其起源于甲状腺滤泡细胞的甲状腺未分化癌（anaplastic thyroid cancer，ATC），恶性程度高，预后差，属难治性甲状腺癌。传统药物及放射性碘治疗ATC效果不佳，是导致甲状腺癌患者死亡的重要原因。近年来，他汀类药物被证实可抑制ATC细胞的增殖和迁移，诱导其再分化，为ATC患者治疗及预后提供了新的研究方向。本文就他汀类药物抗ATC治疗作用及机制做一综述。 |
| 英文摘要: |
| Thyroid cancer is the most common malignant tumor in the endocrine system,and anaplastic thyroid cancer(ATC)originated from thyroid follicular cells has a high degree of malignancy and poor prognosis.It is a refractory thyroid cancer,and the poor effect of traditional medicine and radioiodine therapy is an important cause of death in thyroid cancer patients.In recent years,statins have been proved to inhibit the proliferation and migration of ATC cells and induce their redifferentiation,which provides a new research direction for the treatment and prognosis improvement of ATC patients.Therefore,this article reviews the therapeutic effect and mechanism of statins against ATC. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
