| 闫艳荣,董婷婷,鲁晨.来曲唑和腹腔镜卵巢打孔术治疗多囊卵巢综合征不孕患者临床疗效比较[J].济宁医学院学报,2019,42(4):257-260 |
| 来曲唑和腹腔镜卵巢打孔术治疗多囊卵巢综合征不孕患者临床疗效比较 |
| Letrozole versus laparoscopic ovarian drilling in infertile women with clomiphene citrate-resistant polycystic ovary syndrome |
| 投稿时间：2019-01-20 |
| DOI：10.3969/j.issn.1000-9760.2019.04.007 |
| 中文关键词: 多囊卵巢综合征;不孕;来曲唑;卵巢打孔术 |
| 英文关键词: PCOS;Infertility;Clomiphene citrate;Laparoscopic;Ovarian drilling |
| 基金项目: |
| 作者 | 单位 | | 闫艳荣 | 滕州市中心人民医院, 滕州 277500 | | 董婷婷 | 滕州市中心人民医院, 滕州 277500 | | 鲁晨 | 滕州市中心人民医院, 滕州 277500 |
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| 中文摘要: |
| 目的 探讨来曲唑和腹腔镜卵巢打孔术对克罗米芬抵抗的多囊卵巢综合征（polycystic ovary syndrome，PCOS）不孕患者的临床疗效。方法 选取我院生殖医学中心科2012年1月至2016年12月克罗米芬抵抗的PCOS不孕患者共148例，随机分为来曲唑组（74例）和卵巢打孔组（74例）进行相应治疗，后续随访6个月。结果 治疗前两组患者基本临床特征及血清激素[黄体生成素（Luteinizing hormone，LH）、卵泡刺激素（follicle-stimulating hormone，FSH）、雌激素（estradiol，E2）]水平差异均无统计学意义（P>0.05）。经过相应治疗后，来曲唑组LH水平及排卵率显著高于卵巢打孔组（P<0.05）。注射hCG当天，来曲唑组的子宫内膜厚度高于卵巢打孔组，但差异无统计学意义（P>0.05）。来曲唑组临床妊娠率（33.8%）、活产率（31.1%）均高于卵巢打孔组（23.0%和18.9%），但差异无统计学意义（P>0.05）。来曲唑组流产率（8.0%）低于卵巢打孔组（17.6%），但差异无统计学意义（P>0.05）。结论 与腹腔镜卵巢打孔术相比，来曲唑能明显提高克罗米芬抵抗的PCOS患者排卵率，改善其妊娠结局，该方法更推荐用于临床治疗。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of letrozole and laparoscopic ovarian drilling (LOD) in infertile women with clomiphene citrate (CC) -resistant polycystic ovary syndrome (PCOS). Methods A total of 148 infertile women with CC-resistance PCOS from January 2012 to December 2016 were enrolled and randomly divided into the letrozole group (n=74) and LOD group (n=74).A 6-month follow-up was performed. Results No statistically significant difference was found in the baseline clinical characteristics and the major serum hormone profiles,including luteinizing hormone (LH),follicle-stimulating hormone (FSH) and estradiol (E2) between the two groups.After the corresponding treatment,LH and ovulation rate in letrozole group were significantly higher than those in the LOD group (P<0.05).On the days of the hCG injection,women in the letrozole group had a thicker endometrium than those in the LOD group,however,the differences was not statistically significant (P>0.05) Compared with LOD group,women receiving letrozole had a higher clinical pregnancy rate (33.8% vs 23%) and live birth rate (31.1% vs 18.9%) and a lower abortion rate (8.0% vs 17.6%);however,the differences was not statistically significant (P>0.05). Conclusion Compared with LOD,letrozole significantly increase ovulation rate and improve the pregnancy outcome in women with CC-resistant PCOS.Therefore,letrozole is recommended for clinical treatment. |
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