| 刘新,闫波.SIRT7生物学功能与人类疾病研究进展[J].济宁医学院学报,2017,40(4):295-300 |
| SIRT7生物学功能与人类疾病研究进展 |
| Recent progress of SIRT7 biological function and human disease |
| 投稿时间：2017-04-08 |
| DOI：10.3969/j.issn.1000-9760.2017.04.015 |
| 中文关键词: SIRT7;去乙酰化活性;应激;代谢 |
| 英文关键词: SIRT7;Deacetylase activity;Stress;Metabolism;Human disease |
| 基金项目: |
| 作者 | 单位 | E-mail | | 刘新 | 济宁医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | | | 闫波 | 济宁医学院, 济宁 272067
济宁医学院附属医院, 济宁 272029 | yanbo@mail.jnmc.edu.cn |
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| 中文摘要: |
| SIRT7是烟酰胺腺嘌呤二核苷酸（NAD+）依赖的第三类去乙酰化酶sirtuins家族成员之一。尽管SIRT7 是迄今sirtuins家族中研究最少的成员，但是最近的突破性研究使其去乙酰化活性及生物功能日渐清晰。SIRT7是sirtuins家族中唯一位于核仁的蛋白。在有丝分裂中，SIRT7介导rDNA转录激活。SIRT7通过其去乙酰化活性与P53、H3K18、PAF53、NPM1、GABP-β1和U3-55k等多种底物蛋白相互作用，参与调控细胞增殖、衰老、凋亡等多种细胞进程，并在应激条件下参与调节细胞生存与凋亡的平衡。SIRT7在细胞代谢过程中发挥重要作用，参与恶性肿瘤、心血管疾病、脂肪肝及糖尿病等疾病的病理性进展。本文总结了近年来SIRT 7的研究进展，就其生物学功能与人类疾病的相关性作一综述。 |
| 英文摘要: |
| SIRT7 is a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD+)-dependent class Ⅲ deacetylase.Although SIRT7 is the least studied,recent breakthrough studies have elucidated its acetylation activity and biological functions.SIRT7 is the only one localized to the nucleus in Sirtuin family.During the mitotic process,SIRT7 mediates the activation of rDNA transcription.By interacting with P53,H3K18,PAF53,NPM1,GABP-β1,U3-55k and other substrates,SIRT7 regulates cell proliferation,senescence,apoptosis and other cellular processes.Under stress conditions,SIRT7 plays an important role in regulating the balance of cell survival and apoptosis,as well as metabolisms.SIRT7 has been implicated in the pathological progression of malignant tumor,cardiovascular disease,diabetes and fatty liver.In this review,we summarize the recent progress of SIRT7,focusing on the relationship between its biological functions and human diseases. |
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