| 封伟,张士剑,赵茜.兔双侧上颌窦提升动物模型的建立[J].济宁医学院学报,2016,39(3):161-164 |
| 兔双侧上颌窦提升动物模型的建立 |
| Establishment of an animal model for bilateral maxillary sinus elevation in rabbits |
| 投稿时间：2016-01-12 |
| DOI：10.3969/j.issn.1000-9760.2016.03.003 |
| 中文关键词: 兔;上颌窦提升;动物模型 |
| 英文关键词: Rabbit;Maxillary sinus;Animal model |
| 基金项目:济宁医学院青年基金(JYQ14KJ35) |
| 作者 | 单位 | | 封伟 | 济宁医学院附属医院, 济宁 272029 | | 张士剑 | 泰安市中心医院, 泰安 271000 | | 赵茜 | 辽宁省人民医院, 沈阳 110000 |
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| 中文摘要: |
| 目的 建立兔双侧上颌窦提升动物模型,为上颌窦提升植骨材料的评价研究提供方法。 方法 健康成年日本大耳白兔9只,每只兔行双侧上颌窦提升术,一侧上颌窦提升术区植入生物骨粉,记为实验侧,另一侧上颌窦提升术区不植骨,记为对照侧,分别于术后2、4、8周处死动物各3只,取完整兔上颌骨标本,进行大体观察、X 线检查、组织学评价。 结果 所有实验动物术后恢复良好,均存活至取材,X线检查各时间点实验侧骨密度高于对照侧;组织学观察显示植入骨粉区新生骨组织增加,实验侧在各时间点的新生骨量均优于对照侧。结论 兔有理想的上颌窦提升解剖条件,建立兔双侧上颌窦提升动物模型的方法是可行的。 |
| 英文摘要: |
| Objective To establish an animal model for bilateral maxillary sinus elevation in rabbits and to provide methods for assessment of bone graft materials in maxillary sinus elevation.Methods Nine adult Japanese white rabbits were used in the experiment and bilateral maxillary sinus of every rabbit were elevated,in which one side in bilateral sinus floor elevation with biological bone was the test side and the other side without material was control side.Three rabbits were sacrificed at 2,4 and 8 weeks after operation,respectively.These specimens were treated for gross inspection,X-ray and histological analysis.Results Successful heal was observed in all postoperative rabbits.X-ray assessment showed that bone density in test side was higher the control side.Histological examination showed that,as heal time went,there were more bone tissues formation and the test side was superior to control side at each observed time point.Conclusion The rabbit has ideal anatomic conditions for maxillary sinus elevation and the animal method of rabbit for bilateral maxillary sinus elevation is practicable. |
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