| 董冠军,司传平.IFN-α在SLE发生发展中的作用[J].济宁医学院学报,2016,39(1):6-11 |
| IFN-α在SLE发生发展中的作用 |
| The role of IFN-α in the initiation and development of SLE |
| 投稿时间：2015-01-09 |
| DOI：10.3969/j.issn.1000-9760.2016.01.002 |
| 中文关键词: I型干扰素;干扰素-α;系统性红斑狼疮 |
| 英文关键词: Type I IFN;IFN-α;SLE |
| 基金项目: |
| 作者 | 单位 | | 董冠军 | 济宁医学院基础学院, 山东省泰山学者海外特聘专家实验室, 济宁 272067 | | 司传平 | 济宁医学院基础学院, 山东省泰山学者海外特聘专家实验室, 济宁 272067 |
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| 中文摘要: |
| 目的 I型干扰素在机体抗病毒或细菌感染过程中发挥十分关键的作用。近年来的研究表明, I型干扰素, 尤其是干扰素-α(IFN-α), 在调控机体天然及后天免疫反应的活化方面起到重要作用。系统性红斑狼疮(SLE)作为一种特别难治、病情危及多个脏器的炎症性自身免疫病, 患者体内免疫系统功能严重失调, 但是迄今仍不完全清楚其发病机制。值得注意的是, 大量研究表明SLE患者血清中含有大量的IFN-α, 并且其体内多种免疫细胞中, 包括B淋巴细胞、T淋巴细胞以及粒细胞等, I型干扰素诱导基因的表达水平均显著升高。IFN-α能够引起JAK-STAT1通路活化, 导致机体免疫系统异常活化, 进而影响SLE的发生发展。 |
| 英文摘要: |
| Type I IFNs plays a critical role in anti-virus and bacterial infection.Recent studies show that type I IFNs, especially IFN-α, plays an important role in regulating the activation of innate and adaptive immune responses.Systemic lupus erythematosus (SLE) is an autoimmune disease that involving of multiple organs, multiple systems, clinicalmanifestations of complex, serious harm to human health.The innate and adaptive immune systems of SLE patients are hyper-activated.However, it's still not known the mechanism of the pathogenesis of SLE.Notably, the hallmarks of SLE are productions of amount of IFN-α and multiple studies have shown that many types of immune cells, such as B cells, T cells and neutrophils from SLE patients show significant IFN signature and express higher levels of IFN-inducible genes.IFN-α can activate JAK1-STAT1 signaling and play a vital role in the pathogenesis of SLE. |
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