| 王勇,刘明,胡芳芳.慢性缺血性心力衰竭患者血清N端脑钠肽前体相关性因素分析[J].济宁医学院学报,2015,(4):251-253,257 |
| 慢性缺血性心力衰竭患者血清N端脑钠肽前体相关性因素分析 |
| Relevant analysis of N-terminal pro-B-type natriuretic peptide of the patients with chronic ischemic heart failure |
| 投稿时间：2015-05-15 |
| DOI：10.3969/j.issn.1000-9760.2015.04.006 |
| 中文关键词: N端脑钠肽前体|心力衰竭 |
| 英文关键词: N-terminal pro-brain natriuretic peptide|Heart failure |
| 基金项目: |
| 作者 | 单位 | | 王勇 | 安阳市人民医院, 河南安阳 455000 | | 刘明 | 安阳市人民医院, 河南安阳 455000 | | 胡芳芳 | 安阳市人民医院, 河南安阳 455000 |
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| 中文摘要: |
| 目的 探讨慢性缺血性心力衰竭患者血清N端脑钠肽前体(NT-proBNP)的相关性因素。方法 选取2014年1月至2014年12月安阳市人民医院心内科符合慢性缺血性心力衰竭、纽约心脏协会心功能Ⅰ~Ⅲ级住院患者97名。检测血清NT-proBNP浓度,单变量相关分析确定单变量相关因素;采用逐步多元线性回归分析以确定其独立相关因素。结果 1)年龄、甘油三酯、肌酐、C-反应蛋白、舒张内径指数、收缩内径指数、射血分数、地高辛、心功能分级与NT-proBNP单变量相关。2)甘油三酯、射血分数与NT-proBNP独立负相关(β=-0.328、-0.093,P<0.05),肌酐与NT-proBNP独立正相关(β=0.012,P<0.01)。结论 甘油三酯、射血分数、肌酐是NT-proBNP独立相关因素。 |
| 英文摘要: |
| Objective To determine the relevant factor of N-terminal pro-B-type natriuretic peptide of the patients with chronic ischemic heart failure(CIHF).Methods We screened out 97 patients with CIHF of New York Heart Association Class Ⅰ~Ⅲ.N-terminal pro-brain natriuretic peptide(NT-proBNP)was detected,and the data was analyzed by univariate regression,and stepwise multiple linear regression analysis was used to confirm the independent relevant factor of NT-proBNP.Results 1)Age,triglyceride,creatinine,C reactive protein,end-diastolic dimension index,end-systolic dimension index,ejection fraction,New York Heart Association Class,digoxin were correlated with NT-proBNP.2)Stepwise multiple linear regression analysis showed that triglyceride and ejection fraction independently inversely related with NT-proBNP(β=-0.328、-0.093,P<0.05),creatinine independently positively related with NT-proBNP(β=0.012,P<0.01).Conclusion Triglyceride,ejection fraction and creatinine were the independent correlation factor of NT-proBNP. |
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