| 张冉,王全义,张军臣,于珊珊,王海涛,敖启林.IMP3蛋白及Ki-67在脑胶质瘤中的表达及临床意义[J].济宁医学院学报,2015,(1):28-32 |
| IMP3蛋白及Ki-67在脑胶质瘤中的表达及临床意义 |
| Expression and clinical significance of IMP3 and Ki-67 in hunman gliomas |
| 投稿时间：2014-12-11 |
| DOI：10.3969/j.issn.1000-9760.2015.01.007 |
| 中文关键词: 胰岛素样生长因子IImRNA结合蛋白3;细胞增殖核抗原Ki-67;胶质瘤 |
| 英文关键词: Insulin-like growth factor Ⅱ mRNA-binding protein 3;Nuclcear-associated antigen Ki-67;Brain glioma |
| 基金项目:济宁市科技局2012年计划内科研项目(编号:2012 jnwk04) |
| 作者 | 单位 | | 张冉 | 济宁医学院附属医院, 山东济宁 272029 | | 王全义 | 济宁医学院附属医院, 山东济宁 272029 | | 张军臣 | 济宁医学院附属医院, 山东济宁 272029 | | 于珊珊 | 济宁市第二人民医院, 济宁 272049 | | 王海涛 | 济宁医学院附属医院, 山东济宁 272029 | | 敖启林 | 济宁医学院附属医院, 山东济宁 272029 |
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| 中文摘要: |
| 目的 探讨胰岛素样生长因子ⅡmRNA结合蛋白3(IMP3蛋白)及Ki-67在脑胶质瘤中的表达以及临床意义。方法 选取我院2008年1月至2012年10月手术切除的不同级别的胶质瘤60例(Ⅰ级5例,Ⅱ级20例,Ⅲ级20例,Ⅳ级15例)及5例正常脑组织,应用免疫组化Envision二步法检测IMP3蛋白及Ki-67在不同级别胶质瘤中的表达,分析二者与胶质瘤恶性程度的关系以及二者的相关性。结果 IMP3 在胶质瘤各级别的表达中有统计学意义(χ2=41.17,P<0.05),其中胶质瘤Ⅲ~Ⅳ级阳性表达率明显高于 Ⅰ~Ⅱ级(91.4% vs 8%,χ2=41.34,P<0.05)。胶质瘤标本的Ki-67指数(Ki-67 LI)范围为0%~50%, 在胶质瘤各级别的表达中有统计学意义(χ2=29.80,P<0.05),其中胶质瘤Ⅲ~Ⅳ级阳性表达率明显高于 Ⅰ~Ⅱ级(91.4% vs 20%,χ2=50.29,P<0.05)。IMP3 蛋白的阳性表达率与 Ki-67 蛋白的阳性表达率有正相关性(r=0.774,P<0.05)。结论 IMP3及Ki-67在脑胶质瘤中的表达均与胶质瘤的恶性程度呈正相关,二者联合应用可作为评价胶质瘤级别的重要参考指标。 |
| 英文摘要: |
| Objective To investigate the expression and clinical significance of insulin-like growth factor Ⅱ mRNA-binding protein 3 (IMP3) and Ki-67 in human brain glioma. Methods 60 different grade of gliomas were selected from 2005 to 2012 in our hospital (grade I 5 cases, grade Ⅱ 20 cases, grade Ⅲ 20 cases, grade IV 15 cases) and 5 cases of normal brain tissue. The expression of IMP3 and Ki-67 was detemined in gliomas using immunohistochemistry (Envision method).. The correlation was analyzed between expression of IMP3, Ki-67 and malignant degree of gliomas. And the correlation between the expression of IMP3 and Ki-67 was also analyzed.Results The expression of IMP3 in different grade gliomas was statistically significant (χ2=41.17, P<<0.05) and it was significantly higher in grade Ⅲ-Ⅳ gliomas than that in gradeⅠ-Ⅱ (91.4% vs. 8%, χ2=41.34, P<0.05). The range of Ki-67LI was 0%-50%. The expression of Ki-67 in different grade gliomas was statistically significant(χ2=29.80, P<0.05) and it was significantly higher in grade Ⅲ-Ⅳ gliomas than that in gradeⅠ-Ⅱ(91.4% vs. 20%, χ2=50.29, P<0.05). There was positive correlation between IMP3 and Ki-67 expression in brain gliomas (r=0.774, P<0.05).Conclusion The expression of IMP3 and Ki-67 in gliomas was positive correlated with the grades of gliomas. The united application of them can be used as important reference index for evaluation of gliomas's biological behavior. |
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