| 高慧婕,李春霞,刘树玲,刘超,司传平.人参皂甙Rg3联合槐耳颗粒对免疫抑制小鼠的免疫调节作用[J].济宁医学院学报,2014,(6):399-402 |
| 人参皂甙Rg3联合槐耳颗粒对免疫抑制小鼠的免疫调节作用 |
| Effects of Ginsenoside Rg3 combined with Huaier on immunologicalfunction in immunosuppression mice |
| 投稿时间：2014-07-29 |
| DOI：10.3969/j.issn.1000-9760.2014.06.005 |
| 中文关键词: 人参皂苷Rg3;槐耳颗粒;环磷酰胺;免疫抑制 |
| 英文关键词: Ginsenoside Rg3;Huaier;Cyclophosphamide;Immunosuppression |
| 基金项目:2012年济宁医学院青年科学基金资助项目(编号:JYQ2011KM021) |
| 作者 | 单位 | E-mail | | 高慧婕 | 济宁医学院基础学院, 山东济宁 272067 | | | 李春霞 | 济宁医学院基础学院, 山东济宁 272067 | | | 刘树玲 | 济宁医学院基础学院, 山东济宁 272067 | | | 刘超 | 济宁医学院基础学院, 山东济宁 272067 | | | 司传平 | 济宁医学院基础学院, 山东济宁 272067 | chuanpingsi@163.com |
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| 中文摘要: |
| 目的 探讨人参皂甙Rg3联合槐耳颗粒对免疫抑制小鼠免疫功能的影响。方法 实验小鼠随机分为正常对照组、环磷酰胺模型组、人参皂甙Rg3组以及联合用药组(人参皂甙Rg3+槐耳颗粒)。正常对照组腹腔注射生理盐水,其余各组注射环磷酰胺建立免疫低下模型。正常对照组与模型组每日灌胃生理盐水,人参皂甙Rg3组每日灌胃200mg/kg人参皂甙Rg3,联合用药组每日灌胃100mg/kg人参皂甙Rg3和900mg/kg槐耳颗粒,7d后测定小鼠免疫功能。结果 与模型组比,人参皂甙Rg3组及联合用药组的脾指数、胸腺指数、吞噬指数、血清溶血素含量、淋巴细胞转化率明显提高,联合用药组效果更显著。结论 人参皂甙Rg3联合应用槐耳颗粒可改善免疫抑制小鼠的免疫功能,两种药物有一定的协同辅助作用。 |
| 英文摘要: |
| Objective To investigate the immunoregulation effect of Ginsenoside Rg3 combined with Huaier on immunosuppression mice induced by cyclophosphamide(CTX).Methods ICR mice were randomly divided into four groups:control group,CTX model group,Ginsenoside Rg3 group,Ginsenoside Rg3 combined with Huaier group.The mice in control group received intraperitoneal injection of physiological saline and the other three groups received intraperitoneal injection of CTX(40 mg/kg once a day for 3 days from the 4th day beginning) to induce immunosuppression.The control group and the model group received intragastric administration of physiological saline daily and Ginsenoside Rg3 group received Ginsenoside Rg3 treatment(200mg/kg orally once a day for 7 days respectively),Huaier combined with Ginsenoside Rg3 group received 100mg/kg Ginsenoside Rg3 and 900mg/kg Huaier treatment(orally once a day for 7 days respectively).After 7 days,the phagocytosis of macrophage,the content of serum hemolysin,lymphocyte transformation rate,spleen index and thymus index were analyzed.Results CTX-treated mice showed significant decrease in the number of the phagocytosis of macrophage,hemolysin content,lymphocyte transformation rate,spleen index,thymus index.Ginsenoside Rg3 combined with Huaier significantly increased the number of the phagocytosis of macrophage,hemolysin content,lymphocyte transformation rate,spleen index,thymus index.Conclusion Ginsenoside Rg3 combined with Huaier can notably improve the immune function in immuno-depressed mice induced by CTX. |
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