| 孔霞,柳青,张春燕,孙珊珊.促渗剂对奥美沙坦微乳透皮吸收的影响[J].济宁医学院学报,2014,(2):84-87 |
| 促渗剂对奥美沙坦微乳透皮吸收的影响 |
| Influence of enhancers on the Transdermal Adsorption of Olmesartan Microemulsion |
| 投稿时间：2014-02-15 |
| DOI：10.3969/j.issn.1000-9760.2014.02.003 |
| 中文关键词: O/W微乳;奥美沙坦酯;透皮;促渗剂 |
| 英文关键词: O/W microemulsion;Olmesartan;Transdermal delivery enhancers |
| 基金项目:2006年山东省教育厅课题(编号:J06L59) |
| 作者 | 单位 | E-mail | | 孔霞 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | | 柳青 | 济宁市中医院, 济宁 272000 | | | 张春燕 | 济宁医学院药学院, 日照 276826 | | | 孙珊珊 | 济宁医学院药学院, 日照 276826 | sss-815@163.com |
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| 中文摘要: |
| 目的 探讨促渗剂对奥美沙坦O/W微乳透皮吸收的影响,为奥美沙坦透皮吸收制剂的开发提供依据。方法 以水-油酸-PluronicF-68和Tween-60-正丁醇作为微乳组成部分,制备奥美沙O/W微乳体系,采用 Franz 扩散池,SD雄性大鼠离体皮肤作为渗透屏障,利用紫外分光光度法测定奥美沙坦含量,比较氮酮、二甲亚砜、丙二醇对奥美沙坦透皮吸收的影响。结果 氮酮和二甲基亚砜可明显促进药物的透皮吸收,而丙二醇使微乳中奥美沙坦渗透速率降低到。结论 不同的促渗剂对奥美沙坦的经皮渗透作用影响不同,3%氮酮具有最佳促渗效果。 |
| 英文摘要: |
| Objective To provide guidance and basis for the transdermal preparation of Olmesartan,the influences of enhancers on transdermal adsorption of Olmesartan O/W microemulsion were studied.Methods The O/W microemulison contained Olmesartan was prepared by self emulsified using the mixture of PluronicF-68 and tween 60 as surfactant,butanol as cosurfactant,oleic acid as oil phase and distilled water as the water phase.The transdermal effects of azone,dimethylsulphoxide and propylene glycol to Olmesartan were studied in transdermal experiments in vitro.Drug permeation tests were performed in Franz diffusion cell with two-compartment diffusion cell through excised rats skin.Sample were collected from the receiver compartment.Olmesartan concentration in samples was determined by UV spectrometer.Results Azone and dimethylsulphoxide could obviously enhance the permeation of Olmesartan across the skin of SD male rats.However,propylene glycol weakened the penetration ability of Olmesartan.Conclusion There existed different enhance ability among the above enhancers for Olmesartan across the skin of SD male rats.And 3% Azone had strongest effect on the transdermal permeation of Olmesartan. |
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