| 夏卫东,朱广廷,赵长地.立体定向脑内核团毁损及深部电刺激术治疗帕金森病临床观察[J].济宁医学院学报,2013,(3):185-187 |
| 立体定向脑内核团毁损及深部电刺激术治疗帕金森病临床观察 |
| Effect of stereotactic intracerebral nucleus damage and deep electrical stimulation on treatment of Parkinson's disease |
| 投稿时间：2013-04-11 |
| DOI： |
| 中文关键词: 帕金森病;射频毁损术;脑深部电刺激术 |
| 英文关键词: Parkinson's disease;Radiofrequency ablation;Deep brain stimulation surgery |
| 基金项目: |
| 作者 | 单位 | | 夏卫东 | 济南大学山东省医学科学院医学与生命科学院, 山东济南 250062
济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 朱广廷 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 | | 赵长地 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 |
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| 中文摘要: |
| 目的 探讨立体定向脑内核团毁损术及DBS治疗帕金森病的临床疗效。方法 50例PD患者均在CT/MRI定位下立体定向手术,45例行核团射频毁损术,5例PD DBS均选取STN为手术靶点。术前、术后1月进行UPDRS和ADL的评分,比较手术前后评分的变化和症状改善率。结果 射频毁损术及DBS术后短期效果均满意,显效44例(88%),有效6例(12%),总有效率100%。术后1月的UPDRS与ADL评分较术前均明显减少(P<0.05,P<0.01),术后无明显并发症;随诊射频毁损者复发率8例(17.8%),DBS者无复发。结论 立体定向脑内核团毁损及DBS术治疗帕金森病疗效显著。 |
| 英文摘要: |
| Objective To explore the clinical efficacy of stereotactic intracerebral nucleus lesion and deep electrical stimulation(DBS)in the treatment of Parkinson's disease(PD).Methods 50 cases of PD patients were applied stereotactic surgery in the CT/MRI.45 of patients were lesioned by radiofrequency ablation and 5 of cases were administrated DBS in subthalamic nucleus(STN).UPDRS motor and ADL scores were assessed before and after one month surgery,and the changes of UPDRS and ADL scores and clinical efficacy were compared.Results The short-term effects after radiofrequency ablation and DBS were both satisfied,and the total efficiency was 100% with the remarkable result in 44 cases(88%)and the effective result in 6 cases(12%).The score of UPDRS and ADL decreased significantly compared with the preoperative after a month(P <0.05,P<0.01),and none complication occurred.The recurrence rate was 8 cases(17.8%)by followed up and none patient of DBS recured.Conclusion The curative efficacy of stereotactic intracerebral nucleus damage and DBS is good in treatment of PD patients. |
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