| 管华,崔亚男,温新民.5-氨基水杨酸对乙酰氨基酚酯速释微丸制备工艺研究[J].济宁医学院学报,2013,(3):162-165 |
| 5-氨基水杨酸对乙酰氨基酚酯速释微丸制备工艺研究 |
| Study on the preparation of 5-ASA-AAP immediate-release pellets |
| 投稿时间：2013-04-02 |
| DOI： |
| 中文关键词: 5-氨基水杨酸对乙酰氨基酚酯;固体分散体;微丸 |
| 英文关键词: ASA-AAP;Solid dispersion;Pellets |
| 基金项目: |
| 作者 | 单位 | | 管华 | 济宁医学院药学院, 山东日照 276826 | | 崔亚男 | 济宁医学院药学院, 山东日照 276826 | | 温新民 | 济宁医学院药学院, 山东日照 276826 |
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| 中文摘要: |
| 目的 研制新型高效的抗溃疡性结肠炎药物5-ASA对5-ASA-AAP微丸。方法 以5-ASA为起始物,首先合成对5-ASA-AAP,然后以溶剂蒸发-沉积法制备5-ASA-AAP固体分散体,最后采用挤出滚圆法制备5-ASA-AAP速释微丸。结果 制备的5-ASA-AAP固体分散体在20min内溶出百分率大于60%;粒径在20~40目的微丸收率为83.81%。结论 5-ASA-AAP速释微丸的制备工艺稳定可行。 |
| 英文摘要: |
| Objective To prepare 5-Aminosalicyl-Acetaminophen(5-ASA-AAP)immediate-release pellets.Methods 5-ASA was used as starting material to synthesize 5-ASA-AAP.Then by comparing several measures,the solvent evaporation-deposition method was selected to prepare the 5-ASA-AAP solid dispersion.At last,the 5-ASA-AAP pellets were prepared by extrusion-spheronization technology.Results Dissolution studies showed that the accumulated percentage of 5-ASA-AAP dissolved from the optimal solid dispersion in the first 20 minutes was more than 60%.The weight ratio of pellets between 20mesh and 40mesh was about 83.81%.Conclusion The technique of preparing 5-ASA-AAP pellets is stable and feasible. |
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