| 王慧云.Gemini表面活性剂对类脂囊泡理化性质及pH敏感性的影响[J].济宁医学院学报,2013,(1):9-13 |
| Gemini表面活性剂对类脂囊泡理化性质及pH敏感性的影响 |
| Effects of gemini surfactant on the physical-chemical properties and pH sensitivity of niosome |
| 投稿时间：2013-02-20 |
| DOI：10.3969/j.issn.1000-9760.2013.01.002 |
| 中文关键词: 类脂囊泡;pH敏感性;双子表面活性剂;CHEMS |
| 英文关键词: Niosome;pH sensitivity;Gemini surfactant;CHEMS |
| 基金项目:山东省科技攻关项目(2009GG10002076) |
| 作者 | 单位 | | 王慧云 | 济宁医学院药学院, 山东日照 276826 |
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| 中文摘要: |
| 目的 探讨脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)与抑郁症及其执行功能的关系。方法 随机抽取68例抑郁症患者及71例正常人为研究对象,采用ELASA法检测血清BDNF水平、PCR-RFLP技术检测BDNF rs6265多态位点基因多态性,应用威斯康星卡片分类测验(Wisconsin Card Sorting Test,WCST)评估执行功能。结果 抑郁症组与WCST有关的执行功能明显差于对照组(t=2.02~4.82,P均<0.05);抑郁症组血清BDNF水平低于对照组(t=3.62,P<0.001),其蛋氨酸携带率(89.7%)高于对照组(79.4%)(P<0.05);抑郁症血清BDNF水平与分类数明显相关(r=0.27,P<0.05),携带蛋氨酸组非持续错误数低于非携带蛋氨酸组(z=0.20,P<0.05)。结论 血清BDNF水平及其rs6265多态位点基因多态性与抑郁症的执行功能有关。 |
| 英文摘要: |
| Objective In order to explore the new DDS,the effects of gemini surfactant on the physical-chemical properties and pH sensitivity of pH sensitive niosome were investigated.Methods The pH sensitive noisome was prepared by thin film hydration-ultrasonic method,taking Gemini surfactant,Tween 20,cholesterol and CHEMS as wall material.And the influence of CHEMS and Gemini surfactant on the physical-chemical properties of the noisome were studied by using DLS to measure the variation of vesicle size,PDI,zeta potential and encapsulation efficiency with the increasing concentration of the above two substances.The release rate in different pH buffer solution of the noisome and the fluorescent intensity of the niosome in different buffer solution was also determined after being incubated in the bovine serum for 2h to investigate the pH sensitivity of the noisome.Results The obtained pH sensitive Gemini noisome was almost a monodisperse vesicular system with high encapsulation efficiency high pH sensitivity and the quick release of the enveloped drug in acid environment,moreover the pH sensitive Gemini noisome can hold it's pH sensitivity in the buffer solution containing the bovine serum.Conclusion The prepared pH sensitive noisome can be used to transport of drugs to the target site,and might be explored to an ideal drug delivery system.Key words:Niosome; pH sensitivity; Gemini surfactant; CHEMS |
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