| 王友,王立赞,王保生,张效鹏,胡新远.利多卡因对缺血再灌注家兔心肌NF-κB和血浆ICAM-1 IL-8的影响[J].济宁医学院学报,2012,(6):399-401 |
| 利多卡因对缺血再灌注家兔心肌NF-κB和血浆ICAM-1 IL-8的影响 |
| Effects of lidocaine on myocardial NF-kappa B expression and plasma ICAM-1, IL-8 levels following myocardial ischemia reperfusion in rabbits |
| 投稿时间：2012-10-12 |
| DOI：10.3969/j.issn.1000-9760.2012.06.005 |
| 中文关键词: 利多卡因;心肌缺血再灌注损伤;ICAM-1;IL-8;NF-κB |
| 英文关键词: Lidocaine;Myocardial ischemia reperfusion;ICAM-1;IL-8;NF-κB |
| 基金项目:济宁市2009年科技局项目 |
| 作者 | 单位 | | 王友 | 济宁医学院基础学院, 山东济宁 272067 | | 王立赞 | 济宁医学院基础学院, 山东济宁 272067 | | 王保生 | 济宁医学院基础学院, 山东济宁 272067 | | 张效鹏 | 济宁医学院临床学院, 山东济宁 272067 | | 胡新远 | 济宁医学院临床学院, 山东济宁 272067 |
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| 中文摘要: |
| 目的 研究利多卡因对家兔缺血再灌注心肌NF-κB表达及血浆ICAM-1、IL-8水平的影响。方法 18只家兔随机分为3组(每组6只),假手术组、缺血再灌注组和利多卡因组。测定各组家兔血浆ICAM-1、IL-8的水平,免疫组化方法观察心肌NF-κB表达情况。结果 与缺血再灌注组比较,利多卡因后处理组再灌注后血浆ICAM-1和IL-8浓度明显低于缺血再灌注组(P<0.01),利多卡因可抑制心肌细胞NF-κB的表达。结论 利多卡因可以抑制ICAM-1、IL-8的释放及NF-κB的表达,减轻家兔心肌缺血再灌注后炎性反应。 |
| 英文摘要: |
| Objective To investigate the effects of lidocaine on myocardial NF-κB expression and plasma ICAM-1, IL-8 levels following myocardial ischemia reperfusion in rabbits.Methods Eighteen rabbits were randomly divided into 3 groups (n=6 each):sham operation group, ischemic reperfusion group and lidocaine group.The levels of ICAM-1 and IL-8 in plasma were measured, and the degree of myocardial NF-κB expression was observed by immunohistochemical method.Results Compared with those of ischemic reperfusion group, ICAM-1 and IL-8 concentrations in lidocaine group were significantly lower(P<0.01).Lidocaine also reduced myocardial NF-κB expression.Conclusion Lidocaine could suppress plasma IL-8 and ICAM-1 levels and myocardial NF-κB expression, and alleviate inflammatory response induced by myocardial ischemia reperfusion. |
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