| 张珊珊.岩藻糖转移酶9在子宫颈癌中的表达及临床分析[J].济宁医学院学报,2012,(1):33-35 |
| 岩藻糖转移酶9在子宫颈癌中的表达及临床分析 |
| The expression of fucosyltransferase 9 and its clinical analysis in human cancer of cervix |
| 投稿时间：2012-01-11 |
| DOI：10.3969/j.issn.1000-9760.2012.01.010 |
| 中文关键词: 子宫颈癌|岩藻糖转移酶9|表达 |
| 英文关键词: Breast neoplasm;Fucosyltransferase9;Expression |
| 基金项目: |
| 作者 | 单位 | | 张珊珊 | 济宁医学院附属济宁市第一人民医院, 山东济宁 272011 |
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| 中文摘要: |
| 目的 探讨岩藻糖转移酶9(alpha(1,3)fucosyltransferase 9,FUT9)在宫颈癌组织中的表达及与转移之间的关系。方法 应用免疫组织化学SP法检测60例宫颈癌(其中21例合并转移淋巴结,39例无转移淋巴结)和10例子宫颈炎组织中FUT9的表达。结果 FUT9在子宫颈癌组织中的阳性表达率为76.7%(46/60),其中在转移的淋巴灶中阳性表达率为100%(21/21),而在子宫颈炎组织中表达阳性率仅为10%(1/10)。子宫颈癌组织中阳性表达率明显高于良性宫颈病变组织,两组比较有显著性差异(P<0.01)。有淋巴结转移的宫颈癌组织中的阳性表达率为85.7%(18/21),明显高于无淋巴结转移组的阳性表达率71.8%(28/39),两组比较有显著性差异(P<0.05)。有淋巴结转移组的FUT9表达与TNM分期以及转移的淋巴结个数相关(P<0.05)。结论 FUT9在子宫颈癌组织的表达明显增高,FUT9可能与子宫颈癌淋巴道转移有关。 |
| 英文摘要: |
| Objective To investigate the expression of the fucosyltransferase 9 and its metastasis in human cancer of cervix.Methods FUT9 expression was detected by SP immunohistochemistry in 60 specimens of human cancer of cervix (among these specimens 21 have lymph node metastasis and 39 have no metastasis) and 10 specimens of cervicitis tissue.Results The positive rate of FUT9 was 76.7 %(46/60) in the human cancer of cervix specimens, and 100%(21/21)in the metastasis lymph node.The positive rate of FUT9 in 10 specimens of cervicitis tissue was only 9.1% (1/10).The differences of two sets have statistical significance (P<0.01).Among the cancer of cervix specimens, the positive rate of FUT9 was 85.7% (18/21) in the lymph node metastasis set, and 71.8% (28/39) in the no lymph node metastasis.The differences of two sets have statistical significance (P<0.05).The expression of FUT9 was correlated with TNM stage or the positive lymph nodes (P<0.05) in the lymph node metastasis.Conclusion FUT9 is highly expressed in human cancer of cervix, and related to lymph node metastasis, the positive lymph nodes and TNM stage.FUT9 may be strongly correlated with the process of human cancer of cervix's lymphatic metastasis. |
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