| 马明放,解增洋,孔令栋,李兆楼,刘君,陈瑞蛟.新型大环分子对百草枯包合行为研究[J].济宁医学院学报,2018,41(5):317-321 |
| 新型大环分子对百草枯包合行为研究 |
| Study on inclusion behavior between new macrocyclic molecule and paraquat |
| 投稿时间：2018-09-03 |
| DOI：10.3969/j.issn.1000-9760.2018.05.003 |
| 中文关键词: 葫芦[7]脲;单羟基葫芦[7]脲;百草枯;包合常数 |
| 英文关键词: Cucurbit[7]uril;Monohydroxylated-cucurbit[7]uril;Paraquat;The equilibrium association constant |
| 基金项目:济宁医学院博士启动基金项目（2017JYQD03）；山东省医药卫生科技发展计划（2017WS653） |
| 作者 | 单位 | E-mail | | 马明放 | 济宁医学院基础医学院, 济宁 272067 | | | 解增洋 | 济宁医学院基础医学院, 济宁 272067 | | | 孔令栋 | 济宁医学院基础医学院, 济宁 272067 | | | 李兆楼 | 济宁医学院基础医学院, 济宁 272067 | | | 刘君 | 济宁医学院基础医学院, 济宁 272067 | | | 陈瑞蛟 | 济宁医学院基础医学院, 济宁 272067 | chenrj@mail.jnmc.edu.cn |
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| 中文摘要: |
| 目的 利用光化学反应合成新型大环分子单羟基葫芦[7]脲，对比研究葫芦[7]脲和单羟基葫芦[7]脲在尿素溶液中与百草枯的包合行为。方法 使用光化学反应器合成单羟基葫芦[7]脲，通过质谱和核磁共振氢谱对其结构进行表征；使用紫外分光光度计测定单羟基葫芦[7]脲的表观相对分子质量，以及百草枯在尿素溶液中的摩尔吸光系数；使用紫外滴定方法测定葫芦[7]脲和单羟基葫芦[7]脲在尿素溶液中与百草枯的包合常数。结果 成功合成了单羟基葫芦[7]脲，表观相对分子质量为1419g/mol，百草枯在尿素溶液中的摩尔吸光系数为11000 M-1·cm-1；葫芦[7]脲和单羟基葫芦[7]脲在尿素溶液中与百草枯的包合常数分别为35789 M-1和37684M-1。结论 通过光化学反应可以成功制备单羟基葫芦[7]脲；葫芦[7]脲和单羟基葫芦[7]脲在尿素溶液中与百草枯有着相似的包合行为，包合常数十分接近；葫芦[7]脲和单羟基葫芦[7]脲在尿素溶液中与百草枯均有着较高的包合常数，有望实现对血清中百草枯的吸附，进而起到解毒的功效。 |
| 英文摘要: |
| Objective New macrocyclic molecule monohydroxylated-cucurbit[7]uril was synthesized by photochemical reaction.Inclusion behaviors between cucurbit[7]uril and monohydroxylated-cucurbit[7]uril with paraquat were studied comparatively.Methods Monohydroxylated-cucurbit[7]uril was synthesized by photochemical reactor,then characterized by ESI-MS and 1H NMR.Apparent molecular weight of monohydroxylated-cucurbit[7]uril and molar absorptivity of paraquat in urea solution were detected by UV Spectrophotometer.The binding constants between cucurbit[7]uril and monohydroxylated-cucurbit[7]uril with paraquat in urea solution were measured by UV titration method.Results Monohydroxylated-cucurbit[7]uril was synthesized successfully.Apparent molecular weight of monohydroxylated-cucurbit[7]uril was 1419 g/mol.Molar absorptivity of paraquat in urea solution was 11000M-1·cm-1.The binding constants between cucurbit[7]uril and monohydroxylated-cucurbit[7]uril with paraquat in urea solution were 35789M-1 and 37684M-1,respectively.Conclusion Monohydroxylated-cucurbit[7]uril can be synthesized by photochemical reaction.Inclusion behaviors between cucurbit[7]uril and monohydroxylated-cucurbit[7]uril with paraquat in urea solution are similar.Meanwhile,the binding constants between cucurbit[7]uril and monohydroxylated-cucurbit[7]uril with paraquat in urea solution are almost the same and very high as well.Hence,cucurbit[7]uril and monohydroxylated-cucurbit[7]uril may be used to absorb paraquat in serum and then play the role of detoxification. |
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