文章摘要
王卫平,梁雪迎,谭兴友,姜菲.高浓度5-氨基酮戊酸光动力治疗面部表浅型基底细胞癌疗效观察[J].济宁医学院学报,2017,40(6):417-419
高浓度5-氨基酮戊酸光动力治疗面部表浅型基底细胞癌疗效观察
The effect of high-concentration topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma
投稿时间:2016-12-20  
DOI:10.3969/j.issn.1000-9760.2017.06.008
中文关键词: 5-氨基酮戊酸;光动力;基底细胞癌
英文关键词: 5-aminolevulinic acid (ALA);Photodynamic therapy (PDT);Superficial basal cell carcinoma
基金项目:
作者单位
王卫平 济宁医学院附属医院, 济宁 272029 
梁雪迎 济宁医学院附属医院, 济宁 272029 
谭兴友 济宁医学院附属医院, 济宁 272029 
姜菲 济宁医学院附属医院, 济宁 272029 
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中文摘要:
      目的 探讨高浓度5-氨基酮戊酸光动力对面部表浅型基底细胞癌的疗效。方法 选取2010年10月-2015年10月期间皮肤科门诊收治面部表浅型基底细胞癌患者50例,随机分为治疗组和对照组,每组各25例。治疗组使用40%浓度的5-氨基酮戊酸光动力治疗,对照组使用说明书推荐的20%浓度的5-氨基酮戊酸光动力治疗。每周1次,共3次为一疗程。每3个月复查1次,随诊12个月以观察疗效。结果 治疗组总有效率达100%,对照组总有效率为73%。治疗组总有效率明显高于对照组。两组均无严重不良反应发生。治疗后随诊12个月两组均无复发。结论 40%浓度的5-氨基酮戊酸光动力治疗表浅型基底细胞癌安全有效。
英文摘要:
      Objective We sought to determine the efficacy of ALA photodynamic therapy for superficial basal cell carcinoma(sBCC) using different concentrations of topical 5-ALA.Methods A total of 50 sBCC were analyzed.The patients with sBCC were randomly allocated into treatment group (group A) and control group (group B).The patients in the group A were treated with 40% concentrations of ALA,and the patients in the group B were treated with 20% concentrations of ALA.All patients were treated once a week for three times.All patients were followed up approximately 12 months after treatment to evaluate the clinical results.Results The overall effectiveness rate was higher in group A than in group B.No severe adverse effects were observed in both groups.Conclusion The higher-concentration ALA therapy is effective and safe for sBCC.
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